Safe design and operation of road infrastructure covers a very broad scope. To get results delivered within the work cycle, PIARC Strategic Plan 2016-2019 has put forward 5 specific issues, and TC C.2 Design and Operation of Safer Road Infrastructure has been formed to look into these issues and deliver possible technical contents and materials that would enhance the PIARC Road Safety Manual (RSM). The issues pertinent to vulnerable road users, driver distraction and fatigue, and how human factors should be considered in road design and operations. TC C.2 is expected to contribute to the revision of RSM and also the possible revision of the Road Safety Audit Guidelines taking into considerations of applicability in low and middle-income countries.